‘Acne’
Acne – Physiopathology
June 30th, 2009 | Author: Dr. Fea - Skin Care Specialist
Sebum hyper secretion and hyper keratin channel follicular (due to growth and proliferation acceding corneocytes) lead to the formation pimple which then evolves towards microchist or open pimple.
Micro cysts are the starting points of the inflammatory lesions, papules, pustules of derma wounds their training with larger retention elements retention macro cysts. Comedogenesis explain the mechanisms that are not fully elucidated; it seems that major androgens have propionic bacterium acnes and determinism in the inflammatory response.
Sebum hyper secretion is essential for formation of acne lesions. Sebum glands are under the control of androgenic stimuli and are considered as sebum secretion is triggered and maintained by free testosterone and testicular origin dehydriepiandrosteron and delta 4 androstendion home suprarenal.
Since testosterone dosage in patients with acne may show levels of normal serum and urine, are considered to be a different responsiveness to androgen (a sebum glands) from one person to another. The persons with acnee metabolized more androgens receptors in sebum – pilos (2 up to 20 times more than the healthy subjects).
Cells exist in sebum enzymatic equipment able to convert precursors androgenic metabolites in active sebaceous lipid biosynthesis Material: 17 beta hydroxy steroid dehydrogenase, 3 beta hydroxy steroid dehydrogenase and 5 alpha reductase. Biological endocelular efect produced by these enzymes is dihydrotestosterone which is a hormonal stimulus selective secretion of sebum. The fact that acne is represented equally in both sexes that you sebaceea secretion is under the control of androgenic supra renal and not under the control of testosterone.
Hyper sebum is assessed according to the secretions sebum. On top acne subjects this level is increased and proportionally with the severity of acne. Dosage should not be made only if hormonal forms of acne accompanied by hirsutism or acne resistant to treatment.
Acne
June 30th, 2009 | Author: Dr. Fea - Skin Care Specialist
Acne treatment must take into account the type of acne: retention, or joint inflammation, the intensity and seriousness, the Triggers of any association or other diseases. At the onset of disease lesions retention is reduced clinical picture may be insignificant but the treatment is sometimes difficult.
It is essential that the patient is guided towards the dermatologist, to discuss with the patient, and to explain the evolution of the disease and eradicate preconceived ideas.
Dermatology defines and establishes the potential severity depending on the therapeutic strategy. Of acne lesions induce an increased reactivity to emotional instability, stress, and even dismorfofobie. The dermatologist must be prepared to treat the disease but also to behavioral changes deceleze to take on the psychological support of the patient or to use aid psychologist or psychiatrist.
Acne is a common disease, in part genetically determined, observed especially during pubertara, but also in adults. It is a disease in which coexist polimorfa retention and inflammatory lesions are often on a leather seboreica.